[PDF] The Sleep Heart Health Study: design, rationale, and methods. | Semantic Scholar (2024)

It is concluded that it is feasible to recruit existing participants from one large-scale epidemiologic study into another with a high degree of success, however, the characteristics of the new cohort may vary in several respects from their original cohorts and therefore interpretation of study results will have to consider these differences.

Overall, heartburn during sleep may be associated with sleep complaints and excessive daytime sleepiness, and increased body mass index (BMI), carbonated soft drink consumption, snoring and daytimeSleepiness (Epworth sleepiness scale score), insomnia, hypertension, asthma, and usage of benzodiazepines were strong predictors of heartBurn during sleep.

Although designed as a prospective cohort study, analysis of cross-sectional data from the Sleep Heart Health Study has contributed numerous insights to the field of sleep medicine.

This study demonstrated an association between subjective complaints of daytime sleepiness, inadequate sleep time, insomnia as well as objective measures of severity of SDB, and an indirect measure of healthcare utilization in a community-based sample.

In middle-aged to older individuals, OSA severity is independently associated with higher levels of hs-TnT, suggesting that subclinical myocardial injury may play a role in the association between OSA and risk of heart failure.

Findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated.

In a community-based sample, sleep disordered breathing is associated with higher levels of interleukin-6, a marker of myocardial infarction risk and mortality, and adiposity may mediate the increased levels of C-reactive protein, fibrinogen, intercellular adhesion molecule-1, and P-selectin observed in sleepdisordered breathing.

Although the pattern of associations was consistent with greater obesity in those with higher RDI, higher body mass index did not explain all of these associations.

Among middle-aged and older persons without hypertension, much of the relationship between AHI and risk of incident hypertension was accounted for by obesity, and after adjustment for body mass index, the AHI was not a significant predictor of future hypertension.

Poor SE and long wake after sleep onset, objectively measured by polysomnography, were associated with the increased risk of incident CVD.

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The prevalence of undiagnosed sleep-disordered breathing is high among men and is much higher than previously suspected among women, and is associated with daytime hypersomnolence.

The effect of tracheostomy, independent of age, BMI, and AI at entry, was highly significant, thus emphasizing the need for earlier treatment of the sleep-related abnormal breathing.

The results show that there is a general pattern of factors which predict awake-sleep changes in men and women, but there are also contributing behavioural factors which are sex specific.

The Strong Heart Study, which uses standardized methodology, is designed to estimate cardiovascular disease mortality and morbidity rates and the prevalence of known and suspected cardiovascular disease risk factors in American Indians.

The importance of habitual snoring for the prevalence of hypertension differs in various age groups, and Logistic multiple regression analyses showed that among subjects 40-49 years old there was an average increase in the predicted prevalence of hypertensives from 6.5% among non-snorers to 10.5%, mainly dependent on age and BMI.

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