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, Stuart F. Quan *Department of Medicine and Respiratory Sciences Center, University of Arizona, Tucson, Arizona 1Address correspondence to Stuart F. Quan, M.D., Respiratory Sciences Center, University of Arizona College of Medicine, 1501 N. Campbell, Tucson, AZ 85724, U.S.A. Address reprint requests and requests for the SHHS Manual of Operations and the SHHS Reading Center Manual of Operations to SHHS Coordinating Center, 1501 4th Avenue, Suite 2105, Seattle, WA 98101-1144, U.S.A. Search for other works by this author on: Oxford Academic Barbara V. Howard †Medlantic Research Institute, Washington, DC Search for other works by this author on: Oxford Academic Conrad Iber ‡Department of Medicine, University of Minnesota, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic James P. Kiley §National Heart, Lung, and Blood Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic F. Javier Nieto ‖Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland Search for other works by this author on: Oxford Academic George T. O'Connor ¶Department of Medicine, Boston University School of Medicine, Boston, Massachusetts Search for other works by this author on: Oxford Academic David M. Rapoport #Department of Medicine, New York University, New York, New York Search for other works by this author on: Oxford Academic Susan Redline **Department of Medicine, Case Western Reserve University, Cleveland, Ohio Search for other works by this author on: Oxford Academic John Robbins ‡Department of Medicine, University of California, Davis, California Search for other works by this author on: Oxford Academic Jonathan M. Samet ‖Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland Search for other works by this author on: Oxford Academic
‡Patricia W. Wahl ‡‡Department of Biostatistics, University of Washington, Seattle, Washington, U.S.A. Search for other works by this author on: Oxford Academic
Sleep, Volume 20, Issue 12, December 1997, Pages 1077–1085, https://doi.org/10.1093/sleep/20.12.1077
Published:
01 December 1997
Article history
Accepted:
01 September 1997
Published:
01 December 1997
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Stuart F. Quan, Barbara V. Howard, Conrad Iber, James P. Kiley, F. Javier Nieto, George T. O'Connor, David M. Rapoport, Susan Redline, John Robbins, Jonathan M. Samet, ‡Patricia W. Wahl, The Sleep Heart Health Study: Design, Rationale, and Methods, Sleep, Volume 20, Issue 12, December 1997, Pages 1077–1085, https://doi.org/10.1093/sleep/20.12.1077
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Summary:
The Sleep Heart Health Study (SHHS) is a prospective cohort study designed to investigate obstructive sleep apnea (OSA) and other sleep-disordered breathing (SDB) as risk factors for the development of cardiovascular disease. The study is designed to enroll 6,600 adult participants aged 40 years and older who will undergo a home polysomnogram to assess the presence of OSA and other SDB. Participants in SHHS have been recruited from cohort studies in progress. Therefore, SHHS adds the assessment of OSA to the protocols of these studies and will use already collected data on the principal risk factors for cardiovascular disease as well as follow-up and outcome information pertaining to cardiovascular disease. Parent cohort studies and recruitment targets for these cohorts are the following: Atherosclerosis Risk in Communities Study (1,750 participants), Cardiovascular Health Study (1,350 participants), Framingham Heart Study (1,000 participants), Strong Heart Study (600 participants), New York Hypertension Cohorts (1,000 participants), and Tucson Epidemiologic Study of Airways Obstructive Diseases and the Health and Environment Study (900 participants). As part of the parent study follow-up procedures, participants will be surveyed at periodic intervals for the incidence and recurrence of cardiovascular disease events. The study provides sufficient statistical power for assessing OSA and other SDB as risk factors for major cardiovascular events, including myocardial infarction and stroke.
Sleep apnea, Cardiovascular disease, Epidemiology, Risk factors
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